Nowadays, patients with N-RAS, KIT, and GNAQ mutated tumors can be enrolled in clinical trials of specific inhibitors [ 2, 8– 11].
The SPIRIT 2013 Statement addresses the minimum content for interventional trials; additional concepts may be important to describe in protocols for trials of specific designs (eg, crossover trials) or in protocols intended for submission to specific groups (eg, funders, research ethics committees/institutional review boards).
Challenges in enrollment are not limited to trials of specific disease severities.
Previous clinical trials of specific novel therapies in meningococcal sepsis, targeting pathways of inflammation and coagulation such as recombinant bactericidal/permeability-increasing protein (rBPI) [ 4] and human activated protein C (rhAPC) [ 5], have failed for reasons which are not clear, but which may include case mix.
Besides, changes in pain scores in waiting list control groups and placebo groups in trials of conventional treatments for chronic non-specific neck pain are usually comparable [ 53].
Any future use of such indices in trials of acupuncture in AR should focus on those which have been shown to be helpful in trials of proven therapeutic modalities such as allergen-specific immunotherapy.
More than 1,200 Finns, aged 60-77, took part in a randomised trial of specific interventions.
In randomized controlled trials, usually of specific insulin types or regimens, larger reductions in HbA1c have been reported from baseline levels which bracket those reported here 12, 13.
Future in-human clinical trials of radiotherapy-specific GNPs may shed some light on the impact these particles will have on prostate cancer.
One solution is a universally-agreed core set of outcomes which should be measured, as a minimum, in all clinical trials of a specific condition.
