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In vitro assays demonstrated more than 30% decrease in testicular 3β-HSD and 17β-HSD enzyme activities in treated group of animals.
However, ALT level did not show much change in treated group in comparison to rifampicin control group.
The weight of the animals in treated group with a high dose of MSG was significantly increased in comparison with the control group.
Administration of CCl4 to rats significantly (p < 0.01) increased the relative testicular mass in treated group when compared to control group.
Indeed, longitudinal BLI changes in individual mice were readily approximated as exponential (R 2 > 0.9) in all but one mouse in treated group and one mouse in control group, which allowed for calculation of BLI "doubling time" as a surrogate parameter for changes in metastatic burden.
In treated group, vitellogenic female liver accompanied with the accumulation of lipid droplets and showed enlarged hepatocytes, increased nuclear diameter and large vacuoles in the cytoplasm (Fig. 1d), whereas the liver of control females had large amount of hepatocyte nuclear polarization, vacuolization in cytoplasm and isolated necrosis (Fig. 1c).
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In treated groups, styrene significantly increased fasting blood glucose, plasma insulin (p < 0.001) and glucose tolerance.
Immunocytochemistry confirmed the myosin-positive cells in treated groups and the numbers of these cells were enumerated by flow cytometry.
TCS also induced a perturbed translation of testicular StAR, and AR proteins as shown by Western blot analysis in treated groups of rats.
Decreased vasculature was observed in treated groups compared to control.
It is the result of comparing observed effects in treated groups to the effects observed in the control group.
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