EGF activates glutamine transport via alterations in transporter mRNA levels and the number of functional copies of transporter units.
It has also been reported that l-arginine transport can be rapidly increased by various stimuli in HUVECs, indicating a capacity for regulation of transport independent of changes in transporter protein expression [12,13].
Mutation of Glu22 (32), Glu25 (35), Arg26 (36) or Tyr30 (40) (GkPOT numbering in parentheses) to alanine resulted in transporter variants that could no longer transport under proton driven conditions but could still recognize and transport peptide during counterflow [51].
The genes that are annotated to have a role in transporter activity are primarily involved with either ion transport or secondary active transmembrane transport (Additional file 3B).
On the other hand, the 124 significantly down-regulated genes represented functional enrichment in transporter (GO 0005215) and oxidoreductase (GO 0016491) activities, and in the transport processes (GO 0006810) (Table 3).
Plans to fly the dismantled Chinooks to Nepal in transporter aircraft were first announced on 30 April.
(Like Mr. Statham in "Transporter" mode he manages to doff his shirt in mid-brawl, which prompted howls of delight at the screening I attended).
Human diseases linked to genetic variances, including polymorphisms, insertions and deletions, in transporter genes provide insight into their physiological roles.
The transcriptional variations in transporter mechanisms among the three A. niger strains are presented in Table 5.
This review outlines current research methods in transporter studies, and summarizes the drug-transporter interactions including drug-drug and drug-endogenous substrate interactions.
Since there can be species differences in transporter function, as shown in the present study, different promising radioligands targeted for the brain may be discarded on incorrect conclusions.
