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Patients treated under this protocol experienced a decrease in time to resolution of ~10 hours without increased rates of iatrogenic hypoglycemia or hypokalemia.
Treatment with zanamivir and oseltamivir provided a median reduction in time to resolution of symptoms of between 0.5 and 1.5 days (table 4).
There was no significant difference in time to resolution of SP between the three groups, median (range 25th-75th percentile) for HO = 12 hr (8 27), MO = 12 hr (5 24) and RA = 11 hr (4 24) (p = 0.50).
The primary outcome was time to clinical resolution (hours) of SP. A Cox proportional hazards model was developed to assess differences in time to resolution of SP between treatment groups.
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Note that this result speaks only to the fact that competition has ended, and not which species won; the adaptation speed/accuracy tradeoff is not apparent in time-to-resolution of competition.
There was no difference in the time to resolution of splenomegaly between the treatment groups (P = 0.70).
Treatment trials showed reductions in median time to resolution of symptoms or return to normal activities, or both, of 0.5-1.5 0.5-1.5hich were significant in only two trials.
There was no difference in the time to resolution of SIRS between the two definitive treatment groups (HR 0.91, 95% CI 0.32 to 2.59; p = 0.97).
Secondary outcomes included differences in the time to resolution of DKA and hyperglycemia, average blood glucose during intravenous insulin infusion, mean daily blood glucose after resolution of DKA, length of hospital stay, and hospital complications between treatment groups.
We examined reduction in intracranial pressure, time to resolution of coma, and occurrence of neurological sequelae and death.
The two oseltamivir trials reported a reduction of between 0.4 and 1.5 days in the median time to resolution of illness, defined as resolution of all symptoms and resolution of fever and return to school or normal activities (table 4).
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