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Time intensity curves also showed a slight delay in time to maximum bitterness intensity for the gels with inhomogeneous distributions of hydrocolloids.
Analysis of variance designs showed that hippotherapy intervention program resulted in significant improvements in reaction time and a reduction in time to maximum muscle activity of the intervention group comparing to the control group in all 3 three conditions that were examined (p < 0.05).
Cephalic effects could also help to explain the wide variation in time to maximum gall bladder volume change, which varied not just inter-subjects but also between study days.
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Five published trials 11 12 13 14 15 mostly tested the effects of single doses at selected time points (which can arbitrarily advantage one drug because of the difference in times to maximum effect 16), were largely done in secondary care, and reached conflicting conclusions.
What was also evident in the study was the slight difference in the time to maximum concentration (Cmax) within the eggs, with the 90 mg/kg group reaching Cmax at 24 h post-drug withdrawal and the 30 and 60 mg/kg dose reaching Cmax at 48 h.
In this subgroup, maximum 3-OMG concentration was also less than in healthy subjects (0.25 ± 0.09 vs. 0.37 ± 0.098 mmol/l; P = 0.006); but there was no difference in the time to maximum concentration (80 ± 36 vs. 89 ± 34 minutes; P > 0.05).
No significant differences were found among the three groups in the time to maximum antipyresis (overall mean = 3.6 hours; 95% CI: 3.2 4.0), time to fever reduction by 1°C or the mean hourly temperature from baseline to 6 hours following dose administration.
Except for the difference in dose at which bosentan pharmacokinetics deviate from being proportional, the pharmacokinetic characteristics of bosentan in children and adults, in terms of time to maximum concentration and elimination, are comparable [ 11, 13].
The maximum concentration of drug in plasma (Cmax), time to maximum concentration of drug in plasma (Tmax), and the lag time before quantifiable absorption (Tlag) were taken directly from the observed data.
> -wrap-foot> Cmaximumximum concentration of drug in plasma Tmax: time to maximum concentration of drug in plasma AUC: area under the concentration-time curve Cl: clearance T1/2: half-life The intubation method in this study was based on other endotracheal intubation methods [ 19] and improved by using a 22G "Y" type intravenous catheter.
In this case, we are interested in minimizing the time to maximum of the signal Y; the results for the analysis are presented in Additional file 6: Figure S6A.
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