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The present study also demonstrates that, in this same model, MitoVit E mitigates EtOH-induced accumulation of intracellular oxidants and counteracts suppression of glutathione peroxidase/glutathione reductase (GSH-Px/GSSG-R) functions, protein expression of gamma-glutamylcysteine synthetase (γ-GCS), and total cellular glutathione (GSH) levels.
In this same model, the N-terminal domain alone was targeted to the membrane, suggesting the presence of a membrane-targeting motif within the N-terminus [6].
We recently demonstrated that in this same model, parous female transgenic mice develop mammary tumors with squamous differentiation in the first year of life with an incidence of about 67% [21].
In this same model, everolimus and triciribine also inhibited the growth of trastuzumab-resistant cells.
In this same model system, loss of p16 accelerates UV-induced melanoma development [ 8].
Interestingly, significant molecular changes without corresponding mechanical changes were observed when pregnancy occurred during ligament healing in this same model.
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In 2014, this same model was used to raise the funds needed to buy a thousand pairs of glasses for embroiderers in one of the poorest regions; in 2015, it allowed thirty children who had never seen the ocean to spend a day by the Red Sea.
We will find out thanks largely in part to the organizers of this same model in Germany (which has already funded over 23 years of basic incomes) crossing the Atlantic to attend the Create-A-Thon.
Jean Laborde designed the Queen's Palace in the Rova (built 1839 1841) using this same model on an even grander scale by enlarging the building and adding a third-story veranda.
This same model tested in our current trial's design allowed high levels of dose escalation in previous phase I trials for SABR treatment of liver metastases using 3 and 5 fractions.
This is in contrast to other studies that have shown down regulation of this transporter in the same model [5].
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