Exact(4)
Deacetylation of H4-K16Ac during senescence may explain reported decreases in this mark during mammalian aging and in cancer cells.
The increase in this mark may represent a reaction of proximal promoter chromatin to distal enhancer silenced by Hairy.
Analysis of H4K20me3 in the same regions revealed no decrease in this mark in the Cbx5-/ line.
Very few repressed genes showed any alteration in this mark, thus it appears that repression mediated by Hairy does not require changes in such repressive histone modifications, consistent with our previous report that repression on ftz did not change H3K27me3 levels (Li and Arnosti, 2011).
Similar(55)
For instance, in P20, H3K4me3 accumulated in B, SM and SB, in P21 this mark accumulated in M and B, and in P159 it accumulated only in B. In BM26, the H3K4me3 mark was slightly accumulated in B and SB.
In mammals, this mark mostly occurs in the CpG context, although non-CpG methylation exists, especially in embryonic stem cells.
I have an ancient confidence that lies in my foundation, a dirty blend of emerald and pale skin, beat-up bits that pressed together, compacted over centuries, have left me in this marked up eternal state.
Our goal in this marking was to allow a degree of switching between homeologous chromosomes during the deletion event, and no connection was assumed between two different events.
One is H3K27me1, and it is currently unclear which machinery is involved in setting this mark [ 19].
Yuan Qi's mock results were in the 690s but this mark, in his words, was "ordinary".
The loss of this mark in Chlamydomonas mutant Mut11 resulted in expression of these genes [ 35].
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