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But as expression of a dominant negative N-cadherin also interferes with fibroblast growth factor receptor activation and mitogen-activated protein kinase-extracellular signal-regulated kinase (MAPK-ERK) signaling [45], [46], the precise role of E-cadherin in this context remained unclear.

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However, the molecular mechanisms by which EZH2 contributes to prostate cancer initiation and progression as well as the factors controlling its expression in this context remain largely unknown.

Data about the effect of synthetic DMARDs and/or biological DMARDs in this context remain controversial.

However, its clinical utility and cost-effectiveness in this context remain to be established.

While the precise motivations behind hidden altruism in this context remain elusive, it seems likely that individuals hide donations when these donations violate established norms of behaviour.

The determinants for drug-induced NF-κB activation and the function of activated NF-κB in this context remain to be elucidated.

Even though the diameter of the middle cerebral artery has been documented to be constant during physiological changes in PaCO2[ 19] 19] and up to 90 minutes at a FIO2 of 12% [ 35], the effects of hyperthermia in this context remain to be clarified.

Nonetheless, to date the exact mechanisms underlying the pathogenesis of psychiatric diseases as well as the role of the amygdala in that context remain unclear and further investigations are certainly necessary.

Together with KAI1, CDCP1 has been reported to be a component of the TEM in colon cancer, but its function in this context has remained poorly characterized [ 11].

In this context, questions remain regarding the selection of adequate ductility levels and the corresponding seismic force reduction factor q for a specific class of structures, whereas the detailing requirements to ensure the desired ductility continue to be refined.

In this context, the remaining 49.8% households had no option but to defecate in the open.

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