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Many of the enzyme-coding genes predicted by Met-express encode upstream enzymes in their respective pathways.
Further systematic study of these genes, including T2D candidate genes such as PPARG, IDE, and KIF11, may help elucidate their molecular functions in their respective pathways.
To further explore the mechanism of gene expression involved in hyperthermia-induced damage and repair in the rat small intestine, we investigated the activity of transcription factors AP-1and NF-κB and determined the expression of proteins acting upstream in their respective pathways, using both in vivo and in vitro models.
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In this study, we showed a highly increased solvent tolerance of the ΔfadR ΔmarR double mutant in which two kinds of physiological functions of bacteria were simultaneously changed due to the deletion of regulator genes in their respective pathway: fatty acid synthesis and multidrug resistance (MDR).
In general, these ER-localized transmembrane proteins sense ER stress resulting in the activation of their respective pathways.
Caspases 3, 8 and 9 were measured to investigate potential contributions of their respective pathways of activation in apoptosis [ 41].
Individual proteins targeting regions 27 or 36, and their respective pathways are listed in Additional file 6 : File 1 and Additional file 7 : File 2, respectively.
An overview of the expression patterns of key H. polymorpha methanol utilization and carbohydrate metabolism genes and the interrelationships of their respective pathways is shown in Figure 5.
Genes have been associated to their respective pathways by using Kegg-Pathway (v.2015-04-06) (56, 56).
Our analyses enabled us to position several genes in their respective metabolic pathway, suggesting that these pathways are involved in stress responses.
Yet the positions of Drosophila Sxl and murine Nanos2 in their respective regulatory pathways of germline sex determination remain unknown.
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