Sentence examples for in their normal conformation from inspiring English sources

In their normal conformation, prions serve a still mysterious purpose, possibly aiding memory or enhancing a cell's genetic flexibility.

The absence of the connectivities between G6* NH1) and G16(NH1) or G18(NH1) imino protons indicates that these guanine residues are not in their normal Watson Crick conformations.

Although all of the exact roles of polyamines in these processes are not known, the capacity to interact with DNA and affect DNA conformation are thought to play a role in their normal cellular function (Iacomino and Picariello 1823; Pasini et al. 2013).

Co-author Kurt Wüthrich, also of the University of Zurich, says the new antibody may zero in on the dangerous PrP because it attaches to three different regions of the protein--regions which are distant from one another in the normal conformation, but are close together in the misfolded aggregate.

In its normal conformation, the BH4 domain interacts with pro-death members of the Bcl-2 family and inhibits their toxic function (41).

It can be envisaged that the neo-antigens that arise during the chronic inflammatory response in COPD differ in their protein conformation from ECM proteins expressed in normal lung tissue and that only neo-antigens can be recognized by the immune system.

Protein chaperones play a vital role under both normal and stress conditions by refolding or stabilizing proteins in their correct conformation (reviewed in Gething and Sambrook 1992; Hartl 1996) and are highly conserved among eukaryotes (reviewed in Feder and Hofmann 1999).

Both binding partners were modeled in their rigid conformation, using augmented MM3 parameters [38].

None of these studies show enzymatic activity towards proteins in their native conformation.

Linker histones in their native conformation were obtained from HeLa cell chromatin as described elsewhere [ 30].

In their native conformation they trimerize, forming a tripartite pore [ 13].