Sentence examples for in their dosing from inspiring English sources

Control groups were subjected to the same regimen but received no active drug in their dosing solution.

55 The ability of insulin to lower hyperglycemia in patients with T2DM is stronger than with oral agents, because insulin can be sufficiently titrated to target specific glycemic goals, whether fasting or post-prandial, whereas oral agents are limited in their dosing strategies and maximum daily dosage.

It is unclear why more events are seen with CMF 3-weekly when the chemotherapy DI is lower than classical i.v. Day 1, Day 8 CMF, but it is possible that the patients who received this regimen attended less experienced centres who were less aggressive in their dosing schedule.

However, radiation burden is of concern, and users must be vigilant in their dose reduction techniques, whilst maintaining good image quality which is 'fit for purpose'.

Where compounds are thought to exhibit a threshold in their dose-response curve, a deterministic approach is often adopted in assessing acceptability of exposure (Boobis, 2007).

In such pathways, the genes encoding the nonrate-limiting enzymes would behave as if they were in extremely long pathways because changes in their dose would not alter flux.

However, patients being treated with guideline-directed oral β-blockers (carvedilol or bisoprolol) or oral digitalis preparations for chronic heart failure, chronic AF, and/or chronic AFL could participate in the study under continued treatment without changes in their doses.

Specifically, the approach to chemicals for which there is no evidence of a threshold in their dose-response curve is different from that of chemicals where a threshold is observed or assumed.

Hiller et al., in a study on evaluation of the safety of high doses ILE, reported elevation of AST in all doses of ILE in rats and showed the liver damage in histological studies in their highest doses; although their ILE administration doses were extremely higher (20 80 mL/kg) than our doses [ 41].

One subject withdrew prior to the 672-h blood collection in their first dosing period (SMB).

More precisely, the first dimension of our proposed framework concerns the prescribers of antibiotics, physicians, who may differ in their use, dosing, and choice of antibiotic agents.