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The model of the deprotonated form of the dTTP substrate with the two aspartates in their charged (basic) form seemed to be the most stable and its orientation was in good agreement with X-ray crystallographic structure.
All ionizable protein groups were taken in their charged forms.
According to the NMR structure (entry 1HZ3 [14] in the Protein Data Bank [45]) of the unfolded Aβ in water at pH 5.7, all of the ionizable residues are in their charged states, where H13 and H14 are protonated.
There are two major reasons why logD7.3 of a drug can be high: Some of the compounds had a logP so high (>4.0), that even in their charged form they were still strongly lipophilic (some examples are fluoxetine, sertraline, amitriptyline, imipramine, haloperidol, chlorpromazine, chlorprothixene and silperisone).
Similar(56)
The prosecutors, she said, "have tried to be fair in their charging".
Dual 1850 Rechargeable Backup Battery to be my favorite in their charging arsenal.
Consequently, the modeled EVs are not only differing in their driving profiles but also in their charging behavior.
By then they had three more buses in their charge.
Both men agreed to restrain those in their charge, but rumours of an imminent encounter flew.
Those who betrayed the boys in their charge ought to be made to watch it.
His colleagues looked up to him, and his superiors wanted him in their charge.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com