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Similarly, one can investigate other aspects of fit of the PI in the validation sample, for example, the validity of the proportional hazards assumption.
The model based on the derivation dataset was validated by comparing its performance in the validation sample.
The predictive validity of the instrument was examined in the validation sample by calculating several performance indicators that assess discrimination and calibration.
Plots of observed versus predicted mortality showed excellent model calibration in the validation sample.
Fig. 1 Measurement model with 17 items and four factors, confirmed in the validation sample.
In the validation sample IRT scores generated from the short and long forms were correlated at.96 and the average difference in these scores was -.01.
The resulting multivariable risk index had adequate discriminative power with an area under the receiver operating characteristic (ROC) curve of 0.77 in the validation sample.
In the validation sample, the presence of one or more risk factors would have correctly identified 88% of the test VT patients and 65% of the test bradyarrhythmia patients as needing EP study.
The concurrent validity of the proposed USEI with the UWES-SS, was evaluated by a correlational analysis done in the validation sample (n = 296).
Gene expressions selected at the screening step were then jointly tested in the validation sample for association with the risk factor by multiple regression analysis.
Feature selection was used to identify a set demonstrating the optimal 98% accuracy of the original classification in the validation sample analysis.
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