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One limitation in the use of model organisms is that they are very sparsely distributed across the tree of life.
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In comparison, the pharmaceutical sector has been lagging behind in the use of model-based methodologies.
It examines the pitfalls and problems related to training the non-traditional user in the use of modeling tools.
Overall, the validated experimental results give confidence in the use of modelling for future larger LSCs for BIPV.
Further model advancement, and development of greater confidence in the use of models, is hampered by the lack of thorough evaluation and intercomparisons.
More focus is given to knowledge-based systems, which have apparent advantages over the others in allowing more transparent transfers of knowledge in the use of models and in furnishing the intelligent manipulation of calibration parameters.
A common application is in the use of models that assist local clinical commissioning groups in identifying high-risk patients.
In previous years, there have been substantial advances in the use of models of neuronal microcircuits as forward or generative models of observed electrophysiological responses.
A solution may be found in the use of modeling techniques that can be linked to visual depictions of the population dynamics.
Increased regulatory demands for pediatric drug development research have fostered interest in the use of modeling and simulation among industry and academia.
The number of published quantitative models is growing steadily thanks to increasing interest in the use of models as well as the development of improved software systems and the availability of better, cheaper computer hardware.
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