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T7 RNAP transcribes more rapidly than the E. coli polymerase, resulting in the uncoupling of transcription and translation.
STC1 was also implicated in the uncoupling of oxidative phosphorylation [6], inhibition of macrophage migration in vitro [7] and in vivo [8], prevention of vascular permeablization [9], and both pro- and anti-apoptotic effects [10], [11], [12].
Species differences appear in the uncoupling of migration from that of neural tube closure.
The answer may reside in the uncoupling of P2X7R from cell death.
MDM2 overexpression in mammary epithelial cells resulted in the uncoupling of S-phase from mitosis, causing multiple rounds of DNA synthesis without cell division.
Increased OS during I/R results in the uncoupling of nitric oxide synthase (NOS), which reduces NO production and enhances NOS-derived O2∙− level [ 28].
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In summary, we identified important genes that are altered at the transcriptional level by E6 in our model, in particular the uncoupling of cell cycle regulation (cdc2, cyclin B, cdk2 and cyclin E), down-regulation of pro-apoptotic genes (Fas) and up-regulation of anti-apoptotic genes (Birc5).
Pharmacological interventions to reduce fracture risk are exploring new mechanisms of action, in particular the uncoupling of bone resorption and formation.
He was in Argentina in 2001, when the uncoupling of the peso from the dollar sent the economy spinning.
These increased interactions might occur in the stress recovery phase, in response to the uncoupling of oxidative phosphorylation [66] and a decline in intracellular ATP levels [67].
In any case, the uncoupling of protein and transcript levels has downstream consequences for the cell that may explain many phenotypes of aging.
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