The long-term goals of ENDGAME are to accelerate the identification of genetic susceptibility factors in human disease and the ultimate development of novel and individual disease prevention and treatment strategies through the advancement of genome-wide association study methodologies.
The EGFR-FOXO6-SOX2 signaling pathway regulating expression of the BIM and BMF apoptotic factors thus identifies a feedback loop that may attenuate the effectiveness of anti-EGFR therapy in cancer and contribute toward the ultimate development of drug resistance.
Therefore, genistein's effects on the cell cycle are potentially relevant to its ability to modulate the ultimate development of metastasis in humans.
This is due to the ultimate development of drug resistance in the majority of patients initially responsive to treatment (3-4) and to the presence of so-called primary refractory patients (i.e., those who do not respond from the very beginning) [ 8].
The cumulative result of sequential impaired regeneration may be key to the ultimate development of a dystrophic phenotype in dysferlinopathy.
As the ultimate development of the Bessemer/Thomas process, oxygen blowing became universally employed in bulk steel production.
The width of the Appian Way in its ultimate development was 35 feet.
