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The results show that the burnt Pu fraction in the TOX cycle is much higher, and could be further enhanced for longer irradiations (100 MWd/kg or more).
Per convention, AEs occurring after progression were not included in the TOX state.
Per convention, AEs occurring after disease progression were not included in the TOX state.
Excluding the SNP in the TOX gene region had minimal influence on the correlation of the betas for the remaining 33 SNPs (r = −0.60, P = 2.29E−04).
The highly conserved position of the intron in the TOX HMG domain coding sequence indicates that this is an ancient intron that was present before divergence of vertebrates.
Sensitivity analyses were performed in which utility weights (varying from 0 to 1) were applied to time in the TOX and REL health states.
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We hypothesised that utilities derived from observed SHE values in both the Tox and Rel states would be substantially higher than the arbitrary value of 0.5 used to illustrate the Q-TWiST method when it was introduced (Goldhirsch et al, 1989).
Interestingly, the CWEs, EPM and EPS preparations from A. brassicae induce [Ca2+]cyt elevation, but not the typical disease symptoms of the fungus in Arabidopsis, while the Tox preparation from A. brassicae induces [Ca2+]cyt elevation and is toxic.
In two sensitivity analyses, the TOX state was redefined to include (1) all AEs of any grade or (2) AEs of any grade classified as treatment-related according to the protocol.
Moreover, the examination of diagnostic PCR assays for the detection of the tox gene in clinical samples revealed atypical results in some C. ulcerans strains [ 73], indicating that a reliable diagnostic is necessary for the precise characterization of C. ulcerans strains from clinical specimens [ 74].
This mosquito HMG-box is approximately 90% identical to that found in the mammalian TOX subfamily, despite the considerable evolutionary history separating the two.
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