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In the topical experiment, MAP, HR, rectal temperature, arterial pH, PaCO2, PaO2, base excess (BE) and plasma Na+, K+ glucose and lactate concentrations did not change significantly during the experimental period (Table 1).
Body weight of the eight rabbits in the topical experiment was 3 ± 0.3 kg; it was 3.1 ± 0.1 kg in the nine rabbits of the intravenous administration of JM-1232 experiment, and 3 ± 0.1 kg in twelve animals for the CO2 response experiment.
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Many products have been used in the topical treatment of nail psoriasis; corticosteroids and vitamin D analogs are still the most frequently used topical therapies found in literature.
In the same experiment, topical application of the selective COX-2 inhibitor celecoxib reduced tumor multiplicity somewhat more, ∼60%, but the combination of ONO-8713 and celecoxib had no greater effect [ 4].
In fact, their ability in improving the topical delivery of antiacne agents has been very well established by in vitro experiments [ 125, 126].
In the first experiment, the sensitivity of vessels in tumours to topical application of AC7700 was compared with that of vessels in normal s.c. tissue.
However, for a single document, the number of topics is much smaller than the topical number used in the experiments.
In the experiment measuring TBF change after topical application of AC7700, a special electrode (see below) was used.
All patients were treated with topical 0.05% CsA (Restasis®) for a month as follows: 4 times a day of topical 0.05% CsA (Restasis®), in addition to the topical corticosteroids they were using for the first 15 days, and then 2 times a day of topical 0.05% CsA (Restasis®) after topical corticosteroids were discontinued.
Another experiment involved the topical application of DBP to human volunteers.
This helps in the penetration of the topical medication.
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