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CA is an important intermediate in the TCA cycle.
The biochemical reactions in the TCA cycle are catalyzed by a number of enzymes.
Oxaloacetate is an important intermediate chemical in the TCA cycle, glycogenesis, and aspartic acid biosynthesis.
(4) Mutations in metabolic enzymes are found mainly in three enzymes involved in the TCA cycle.
Succinate dehydrogenase (SDH), also known as complex II, has roles in the TCA cycle and the ETC.
Oxaloacetate can also be oxidized in the TCA cycle.
Aspartate derived from oxaloacetate (OAA) is an intermediate precursor in the TCA cycle.
The genes korA, korB, and acn encode enzymes that are involved in the TCA cycle.
This is consistent with the many other metabolic roles these enzymes play apart from their place in the TCA cycle.
The presence of these genes in the TCA cycle in L. reuteri has been demonstrated indirectly previously [47].
Correlating with the metabonomic observations, the microarray analysis indicated alterations in the TCA cycle, albeit at low levels.
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