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We started by quantitatively evaluating how closely related the drugs in the shared components are in terms of known chemical biology relationships and compared our data with those of two previous studies (Iorio et al., 2010; Khan et al., 2012) that investigated drug actions using the same CMap database version.
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In most cases, the shared components are not visible to customers.
For convenience, the clusters and the corresponding compositional signatures were named with a letter identifying the labeling set from which they were resolved (A D), and a number such that signatures of different labeling sets that are similar (in respect to the shared components of these sets) carry the same number (Fig. 3 and Table 2).
The layout algorithm beautifully clusters each of the celebrity's networks together, and keeps the shared components in the middle.
We next analyzed the shared components in detail.
41, 42 In particular, osteoimmunology focuses on the shared components and mechanisms between the two systems, which include ligands, receptors, signaling molecules, and transcription factors.
The detailed structure response relationships discovered from all the shared components are visualized in Supplementary Figure S1 and tabulated in a usable format in Supplementary Table S2.
In the first case, we examine how changes in production of the shared component, X, are propagated to affect the levels of free A and B, and the levels of the complexes AX and BX, and therefore modify both pathways in which X participates.
Fig. 4 Posterior median relative risks for disappearance and homicide in El Salvador from the shared component model.
We will examine some scenarios which draw a direct contrast with the purely temporal signal processing in the case where the shared component, X, is modulated.
The general structure of the shared component model in (1) and (2) is discussed in Lawson (2013, p. 209).
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