Multiple hypomorphic alleles of genes in the same pathway may have synergistic effects.
Fourth, genes that function in the same pathway are often co-regulated, and therefore co-expressed across various growth conditions.
Genetic data indicate that DNA topoisomerase 2α acts in the same pathway of telomere protection as TRF2 and Apollo.
Genes in the same pathway can retain their function in organisms separated by a billion years of evolutionary history.
These results are consistent with RAB-5 and PMK-3 functioning in the same pathway to stimulate GLR-1 endocytosis.
Nevertheless, it seems probable that the 12 18 mers are formed in the same pathway Aβ fibril formation.
Given that metformin effects require both AMPK and SKN-1, we wondered whether they act sequentially in the same pathway.
Moreover, the genetic interactions between the two genes suggest that they do not act in the same pathway.
Coincident detections of a metabolite in the same pathway, and correlation on the PC1 axis lend some support.
In support of this hypothesis, epistasis experiments suggest that FimL and CyaB function in the same pathway.
We hypothesized that multiple variants in genes in the same pathway may jointly contribute to the association with disease status.
