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It is only in the case of independent insertions occurring within a very narrow window (<25 bp) and in the same orientation, that parallel insertions become a problem, a problem that is not unique to the ME-Scan protocol.
Carefully reconnect any power cables to the new lamp if present and slide the new lamp into the compartment in the same orientation that the original lamp came out.
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Many of the ROCK and GRK inhibitors characterized structurally thus far contact the hinge with the edge of a planar, usually aromatic ring system that binds in the same orientation as that of the adenine ring of ATP.
The random variable O n is binary, with O n =0 indicating that the sequence of read n is in the same orientation as that of its parent isoform, and O n =1 indicating that it is reverse complemented.
We note that the insertions of P[lacW]l(2 k11209 in pkn k11209 and P[lacW]k06808 in pkn dln are in the same orientation such that the 5′ terminus and 3′ terminus of the P[lacW] element have the same relative orientation as transcription from the pkn gene.
For example the rDNA loci in Escherichia coli are arranged in the same orientation as that of replication fork passage.
The integrated viral fragment contains the same DNA inverted repeats in the same orientation as that which characterizes the EsV-1 genome.
Remarkably, productive transcription elongation across PERs is usually directional, predominantly in the same orientation as that of the nearest downstream gene.
For each gene, we then looked for neighboring genes predicted to be transcribed in the same orientation and that lay within 1 kb.
18 PRAME-like genes and 15 pseudogenes were predicted in the orthologous region of mouse chromosome 4. (These are numbered sequentially Mus_1, Mus_2 etc., in the same orientation as that used for the human and chimpanzee numbering scheme).
The Thr-481 side chain is in the same orientation as that of Ala-481, with the Cγ methyl pointed towards the protein interior and the Oγ alcohol extending into the t1-binding site.
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