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We first describe studies implicating lysine methylation in regulating early steps in the replication process.
For SARS-CoV, at least 17 proteins, including 16 non-structural proteins and the structural nucleocapsid protein, are most likely involved in the replication process [12], [53].
These two observations seem contradictory as cyclin E is involved in the transition from G1 to S. We therefore hypothesized that hPaf1 could act in the replication process.
Small molecule inhibitors of RNA virus replication are potent antiviral drugs and useful to dissect selected steps in the replication process.
These cases are likely to create frequent pause events in the replication process.
ERTBV integrations likely occurred when the virus was in the replication process, and were preferentially targeted to AT-repeat sequences.
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Replication by these viruses is termed low fidelity because RNA mutations, due to imprecision in the replication processes, lead to a wide diversity of genetic variations in progeny.
In E. coli, the replication process usually terminates at a narrow region that includes approximately 5% of the genome length and is located directly opposite the replication origin [ 39- 41].
The roles of a dozen host factors involved in various steps of the replication process have been validated in yeast as well as a plant host.
This could be a good explanation for the strand-slippage theory with an assumption that there is no bias in the rate of mis-pairing in genomic regions during the replication process.
The L. hongkongensis genome contains three copies of dam and one copy of the hda gene which are likely involved in the regulation of the replication process.
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