Traditionally recognized for their role in regulating lipid absorption, bile acids are now known to be involved in the regulation of multiple metabolic processes including lipid and glucose metabolism and energy homeostasis through the activation of multiple signaling pathways.
EVs play a pivotal role in the regulation of multiple systemic pathophysiological processes.
SA and NO are participating in the regulation of multiple physiological processes and plant resistance to biotic and abiotic stress.
Rac GTPases are involved in the regulation of multiple cell functions and have been implicated in the pathology of certain human diseases.
Some of the distal interactions were validated by siRNA knockdown experiments, including a locus involved in the regulation of multiple transcripts involved in the ER stress pathway.
Polycystin-1 is a very large transmembrane protein with a long extracellular part and short cytoplasmic tail, which is involved in the regulation of multiple pathways, some of which are linked to growth control [10].
The transforming growth factor-beta (TGF-β) superfamily member, activin A, plays a central role in the regulation of multiple physiological processes including cell differentiation, mitogenesis, embryogenesis, apoptosis and inflammation.
In line with their diverse repertoire of signaling functions, ROR receptors are involved in the regulation of multiple processes in embryonic development such as development of the axial and paraxial mesoderm, the nervous system and the neural crest, the axial and appendicular skeleton, and the kidney.
The Notch-RBP-J signaling pathway is involved in the regulation of multiple lineages of stem/progenitor cells.
Intriguingly, CSE1L included in the intracellular transport category is involved in the regulation of multiple cellular mechanisms, proliferation, and apoptosis [45].
Since SUMO modification participates in the regulation of multiple protein functions, repression of sumoylation may mediate a number of NO-related cellular events and pathological processes.
