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One possibility is that transcriptional E2F1 targets could regulate, directly or indirectly, genes involved in the regulation of functions of the endosomal compartment, as per exemple those for the rag proteins.
The identification of the transcriptional regulons involved in the regulation of functions required for bacterial persistence could significantly advance knowledge on specific P. aeruginosa adaptation to the environment of the CF lung.
The importance of miRNAs in the regulation of functions such as cell differentiation, development and apoptosis was highlighted early after their discovery, and it is now known that aberrant miRNA expression is seen in many human diseases, including cancer, where miRNAs can act as oncogenic miRNAs or as tumor suppressors.
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Maintenance of cell junctions plays a crucial role in the regulation of cellular functions including cell proliferation, permeability, and cell death.
The beta-1 adrenergic receptor (β1AR) plays a fundamental role in the regulation of cardiovascular functions.
ECM plays an important role in the regulation of chondrocyte functions.
Ca2+ plays an important role in the regulation of nuclear functions [ 43, 44].
Its role in the regulation of mitochondrial functions has drawn more attentions [ 26].
Posttranslational modification of proteins by phosphorylation plays a critical role in the regulation of protein functions and in protein-protein interactions [ 21].
The underlying mechanisms of these effects can relate to the role of LETM1 in the regulation of mitochondrial functions.
Together, these results lead us to propose that CTMP has a major function in mitochondrial dynamics and could be involved in the regulation of mitochondrial functions.
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