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Despite RECREATE's tighter glycemic targets, symptomatic hypoglycemia was infrequent and occurred in fewer participants in the RECREATE trial (2.0%) compared with other AMI studies (3.5 3.8%) (Table 2) (12, 14, 14).
Overall, 287 participants were enrolled in the RECREATE trial (273 in India, 13 in Canada, and 1 in Argentina).
The intravenous insulin algorithm used in the RECREATE trial achieved lower glucose levels than other published clinical trials of insulin therapy in AMI (Table 2).
We then tested the feasibility, safety, and effectiveness of this approach in the AMI setting in the RECREATE (REsearching Coronary REduction by Appropriately Targeting Euglycemia) pilot trial.
Possible explanations for the lower achieved glucose levels in the RECREATE trial include the following: tighter glycemic targets, the use of insulin mixed in normal saline instead of a glucose-based solution, and a lower percentage of participants with preexisting diabetes (27.5 vs. 48 100%).
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