Among patients who were fully compliant with the protocol, however, the reduction in A1C was significantly greater in the PRT group (PRT −0.96 ± 0.93%, P < 0.001; CSII −0.55 ± 0.93%, P < 0.001; intergroup comparison, P = 0.004) (Fig. 1 B).
The document may modify the plans outlined in the study protocol; however any major modifications of the primary endpoint definition and/or its analysis are also reflected in a protocol amendment.
The third protocol also involved the use of the 'magic wand' tool in Avizo 3D imaging software as a 'region-growing' tool, similar to that utilized in the second protocol; however, in this case, segmentation was performed using a mixture of an automated approach with manual localized visual refinements to the tooth structure.
Up to a maximum of four AFI+ areas were included in the research protocol; however, small AFI+ areas (<1 cm) within 1 cm from the gastro-oesophageal junction were excluded due to the well-known false positivity in close proximity to the gastric folds.
No subject was withdrawn from the study because he/she met the criterion for withdrawal as a result of GI AEs as defined in the study protocol; however, three out of 129 subjects were withdrawn because of GI AEs at the request of the investigator.
In the Kyoto Protocol, however, it may not always work.
In the original protocol, however, measurements are made by a blood gas analyzer that is not accessible to our unit.
Subgroup analyses were not specified in the study protocol, however costs were summarised for a number of clinically relevant groups, including patients classified as suffering major haemorrhage (receiving four to nine units of PRBCs in 24 hours), and those suffering massive haemorrhage (receiving 10 or more units of PRBCs in 24 hours).
The approaches in [2 5] based on the AP's polling can be implemented by modifying the PCF protocol; however, in the approach in [5] the assumption that the AP knows each ACK frame transmission time beforehand makes piggybacking the uplink data frames on the ACK frames difficult.
The LOGIC-Insulin software required more frequent blood glucose measurements than in the nurse-directed protocol; however, the obtained sampling interval of 2.2 h falls in the 2 3 h range that is applicable in routine glucose management protocols in at least three ICUs across Europe (38).
