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Since this baseline offset was not correctable using the normalization schema applied, these spectra were excluded from further analysis in the proof of principle experiments presented, yielding 100 patients available for analysis.
Moreover, Dll1-triggered positive influence on MAB differentiation seems confirmed in the proof of principle of Dll1 overexpression with the aberrantly myogenic Sgcb-null MABs.
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Therefore, the study design was able to provide some interesting information in addition to the proof-of-principle of the SDA method.
For now, they are in the proof-of-principle phase of their work.
In the proof-of-principle experiment, good agreement with the theoretical predictions is obtained.
The experiments and simulations demonstrate good correlation in the proof-of-principle study conducted here on a martensite ferrite dual-phase steel, and deviations are discussed in terms of limitations of the techniques involved.
Although the technique is still in the proof-of-principle stage, it "could be an immensely powerful tool in implementing conservation measures for the most at-risk bird populations with fine-scale precision," says Jeff Wells of the Boreal Songbird Initiative in Seattle, Washington.
In the proof-of-principle classifier, bootstrap estimates predicted the 7-biomarker model would have an accuracy of 87% on stage I samples.
We observed that while TaqMan probe had higher hybridization efficiency, shared-stem molecular beacons had lower background when the probe type was exchanged in the proof-of-principle assays.
Including inhibition from SOMs to PVs in the proof-of-principle model supported experimental findings.
In the proof-of-principle experiments, the authors benchmarked the method against 210 PDZ-peptide interactions of known affinities.
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