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Several derivatives have shown a marked cytotoxicity with IC50 values in the nanomolar range.
Compounds were active in the nanomolar range.
Most of the target compounds exhibited potency levels in the nanomolar range.
The standard binding free energy value is close to the experimental Kd in the nanomolar range.
Pharmacological studies revealed high hCA IX inhibitory potency in the nanomolar range.
These agents exhibited higher progesterone receptor binding affinities in the nanomolar range and intracellular accumulation.
Most of the compounds were found to inhibit AChE in the nanomolar range.
They show high selectivity to the MAO-B isoenzyme, with IC50 values in the nanomolar range.
Compounds 2a and 2d showed excellent enzyme inhibitory activity with IC50 values in the nanomolar range.
Functional activity of these compounds showed full agonist activity with EC50 in the nanomolar range.
In both cases, the recombinant WT protein and its mutant version, the calculated KD was in the nanomolar range indicating a high affinity for IFN-I.
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