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New types of hypotheses can be easily integrated in the methodology without having to revisit the prediction mechanism.
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In this development, in situ water and water production are neglected but could be included without change in the methodology.
The authors decided to add this test (without changing anything in the methodology) after the beginning of the work, so the level of IL-8 was collected in only 36 subjects.
No grand scam hidden in the methodology.
Was there a fluke in the methodology?
The proposed methodology is presented in "The methodology" section.
In conclusion the experiments performed in laboratory confirmed the possibility to apply the methodology in-situ without any risk for the statue of "Ratto delle Sabine" model.
The wide variation in the relationship between dose and levels has also indicated the difficulties in spot sampling methodology without a population pharmacokinetic model [37], as well as the potential impact from the subject's inhalation technique, particularly when an MDI device is used [38 40].
Now, I believe in both the methodology and the philosophy of this approach.
In country, the methodology included 1.
We do acknowledge some arbitrariness in our choice of methods and thresholds; most of these were chosen to show significance in our methodology without adding complexity.
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