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Information on TEM crystal structures was also included in the LacED.
The inconsistencies were reconciled in the LacED based on the information from the TEM mutation table.
The wrong name assignment is corrected in the LacED if the mutation profile is included in TEM mutation table.
Amino acid sequences which differed by at least one residue from the TEM-1 seed sequence were stored in the LacED as a new protein entry.
For each protein entry in the LacED, a pairwise sequence alignment with the TEM-1 β-lactamase sequence was performed using ClustalW [ 14].
In the first case, the sequence was considered as a new TEM-like sequence, in the second case the information of this entry was corrected according to the TEM mutation table and stored in the LacED.
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