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Bader, E. et al. Identification of proliferative and mature β-cells in the islets of Langerhans.
Total number of beta-cells in the islets were counted using Imaris (Bitplane).
FXR is predominantly cytosolic-localized in the islets of lean mice, but nuclear in obese mice.
Moreover, glucose-stimulated insulin secretion (GSIS) is impaired in the islets of FXR−/− mice.
These actions of insulin are opposed by glucagon, another pancreatic hormone produced by cells in the islets of Langerhans.
This type of stimulation occurs when glucose enters insulin-producing beta cells in the islets of Langerhans of the pancreas.
Erik Bader, E. et al. Identification of proliferative and mature β-cells in the islets of Langerhans.
The different cell types then combined with each other in much the same architecture as do cells in the islets of the pancreas.
Recent studies suggested the presence of immature, Ucn3-negative and insulin-positive cells in the islets from donors with type 2 diabetes.
T cell mediated loss of insulin-secreting β cells in the islets of Langerhans is the hallmark of type 1 diabetes.
Similar to previously reported amyloid deposits in the brain and heart, amyloid deposits were found in the gut; however, no amyloid deposited in the islets.
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