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One study observed increased rates of IPF in the IPC group (33% versus 13%) [ 31], whereas the remaining study showed a trend towards increased IPF in the IPC group (11% versus 0) [ 32].
Intraoperative blood loss was reported in all 6 studies with mean IOBL of 691 and 729 mL in the IPC and non-IPC group, respectively.
The duration of ICU admission was reported in 5/6 studies with a mean of 2 and 2.5 days in the IPC and non-IPC group, respectively.
Perioperative mortality was reported in all 6 studies with a mean perioperative mortality of 1.4% and 1.9% in the IPC and non-IPC group, respectively.
Peak AST was reported in all 6 studies with mean levels of 223 and 502 IU/L in the IPC and non-IPC group, respectively.
Histological evaluation showed no structural damage in the IPC group and an improvement in the IPC-IR group compared to IR alone.
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However, the Kurs-6 driver is expressed in the ipc-1 cells (Fig. 5C).
In conclusion, reducing DTK or sNPF levels in the ipc-1 and ipc-2a cells both lead to increased sensitivity (or decreased resistance) to both starvation and desiccation.
Similarly, the Kurs-6 driver should only affect ITP levels in the ipc-1 neurons of the larva, but not sNPF or DTK.
Loss of either of the two peptides in the ipc-1 and 2a neurons also diminished the flies' water conservation at desiccation.
These findings prompted us to investigate whether the peptides in the ipc-type neurosecretory cells play a role in responses to desiccation.
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