Authors' response: The differences in post-translational modification, protein structures, cleavage site, etc, may have influence in the interacting residues and interaction interfaces, which count a lot when transferring interactions from intra-species PPI to inter-species PPIs.
Most paths consist of direct interactions between proteins in the interacting pathways (Additional file 1, Figure S4).
In the "Interacting RDE" section, we describe the main features of the interacting RDE model.
We show that conserved charged amino acid residues in the interacting motifs are necessary for the protein-protein interaction.
While there was more than 80% commonness in the interacting residues on the binding sites which play an important role in hydrophobic interactions for compounds 7 and 13.
Likewise, protein-protein or lipid-protein interactions can be founded in the occurrence of numerous distinct interfaces in the interacting protein(s) [11, 12].
There they trigger gene silencing in the interacting organism, a phenomenon called cross-kingdom RNAi.
Presence of lubricant shows the negation of effect of weight percentage of particulate in the interacting surface region.
However, as the average partial charge increases in the interacting hydrogen atoms in the polyatomic cations, the binding energy increases.
Similarly, psychiatric illness arises from abnormalities in the interacting circuits and neurotransmitter systems of the brain, many of which will overlap with those regulating sleep and circadian rhythms.
We show using the one-dimensional model, that the meniscus does not always lead in the smallest radius capillary in the interacting system.
