Exact(29)
Through the use of quality tests, the database provides a means to improve overall data integrity and illustrates the magnitude, sources, and types of errors present in the initial dataset.
This could again be the result of the high variability in the initial dataset thus affecting the deduced natural template.
Out of 1225 stocks in the initial dataset, 214 stocks meet this criterion for at least one of the subperiods.
Not scaling the input data may as well allow for subtle, yet useful, transformations applied in the initial dataset to be expressed in the restructured principal components.
It is crucial to note that the number of data points in the initial dataset depends on the size of search space.
While these particular clusters are of varying strengths, finding such a wide spread in the initial dataset somewhat reinforced our belief that an approach which accommodates several naturalness templates (deduced from the clusters identified in the initial dataset) may be the best way to proceed in the future.
Similar(31)
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1472-6963/12/65/prepub The authors would like to acknowledge the contribution made by the staff at the General Practice Research Database and Tarita Murray-Thomas in particular for all her help in creating the initial dataset and for assistance with questions during analysis.
For this purpose we employ the Significance Analysis of Microarrays (SAM) algorithm [ 17], which performs multiple gene specific t-tests on permutations of the initial dataset, in order to account for the initially enormous number of input genes.
We trained and respected the ratio between positive (2100) and negative (12,000) samples, as used in [9] at the initial dataset.
In such cases, we preprocessed the initial dataset to filter only for the desired information (i.e., including only genes that are up or down-regulated).
According to a GOstat comparison, genes from asymmetrically evolving gene pairs are not significantly different (P < 0.01) from other genes of the initial dataset in terms of protein function.
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