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We examine several evolutionary parameters inferred from alignments in which the only difference is the method used to select the protein isoform combination: Longest, PALO, the combination that results in the highest sequence conservation, and a randomly selected combination.
Similar(59)
The opposite scenario, in which the highest sequence similarity is seen in phylogenetically distant species, would constitute evidence for convergent evolution between PrPC and ZIP10 sequences.
In contrast, LFY2int2-N showed the highest sequence divergence, resulting in the best-resolved tree.
As shown in Fig. 6a, the highest sequence homology hits correctly produced the most accurate Nest-built models.
We examined the three novel predicted miRNAs with the highest sequence counts in more detail.
However, the toxins may be ribonucleases in view of the high sequence similarity to toxins in the other clusters identified.
However, it does not seem to have had this affect in light of the high sequence homology of isolates in this study.
This is in agreement with the higher sequence identity between bird Kp(10 -like and the other sauropsid Kp2(10 -like
In this scenario perhaps the high sequence similarity of these segments led to their annotation as segmental duplications.
There are still some remaining challenges for the usage of WES in large-scale case control studies, in particular the high sequencing price combined with the need for big sample sizes.
However, despite the high sequence similarity in the ATP binding pocket, several groups including ours have been able to develop highly potent and selective ATP-competitive inhibitors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com