All these genes are down-regulated following siRNA-induced CD49e knockdown in human TEC, strongly indicating the existence of a highly complex intracellular molecular circuitry in the thymic epithelium, controlling the expression of various genes involved in physiological guidance of developing thymocytes within the thymic lobules.
In accordance with the MRC guidance of developing and evaluating complex interventions [ 54, 55], the current project aims to elucidate the interactive components of individual music therapy.
Thus, our data suggest that Megf8 is involved in mediating BMP4 signaling and guidance of developing TG axons.
These findings suggest that Megf8 mediates guidance of developing TG axons in a cell autonomous manner.
33 Additionally, NHS has been working on developing a generic approach to transition care in England, 34 and the National Institute for Health and Care Excellence NICEE) is in the process of developing a guidance document on transition to be published in February 2016.
However, despite these limitations, the findings provide some guidance for future work in the area of developing interventions to increase exercise post hip fracture, as well as measurement challenges for social cognitive constructs post hip fracture (ie, accurate assessment of self-efficacy and outcome expectations).
Screening for congenital abnormalities was performed under the guidance of a specifically developed checklist.
We assessed the quality of sample size determinations reported in research protocols with the aim of developing guidance for research ethics committees.
Dr. Haeussermann was in charge of developing the guidance and control systems for the Redstone, a ballistic missile with a range of about 150 miles, and then the Jupiter, with a range of 1,500 miles.
Given the challenges of developing guidance in this area, choosing the most appropriate topics for further study is of fundamental importance.
