In fact, the general developmental and anxiety literature includes many real-time observational studies of parents interacting with their children; however, these are mostly families from the general population or clinical samples that are not necessarily trauma exposed, participating in brief non-naturalistic observations (ie, families are given a particular task and are taped).
In addition to the above compounds known to affect NC cells in vivo and in vitro, we also tested the general developmental neurotoxicants CH3HgCl and Pb(CH3CO2 4, which have not been characterized for their effects on NC cells.
The role of dsx in sexual differentiation has been demonstrated in D. melanogaster 52– 54, M. domestica 16 and the lepidopteran Bombyx mori 55, indicative of an ancestral role in integrating sexual differentiation within the general developmental program 56– 63. tra genes in insects may also regulate the fruitless (fru) genes that encode a BTP zinc-finger transcription factor sex-specifically 64.
This is consistent with the results of previous studies based on molecular data [6], [23], [48], and supports the findings that some morphological/morphogenetic features of these genera, e.g. the cirri of the midventral complex are not arranged in the zig-zag pattern, and the general developmental process of the ciliary structure, are more similar to those of discocephalines than urostylids [49].
But identifying key genes responsible for the general developmental failure in cloned embryos is not an easy task, since the alterations may be caused by a variety of factors including donor cell type, cell cycle stage, nuclear transfer protocol, source of the oocytes, embryo culture system, embryo transfer procedure, recipient cows management, and operators' skills [ 42].
The general developmental role can be broken down further.
However, despite the undisputed central role that Tip60 plays in the regulation of general developmental gene control, the question of whether the epigenetic HAT activity of Tip60 is required for differential tissue-specific gene expression profiles essential for organismal development remains to be explored.
These results imply that some SR proteins may be involved in a general developmental response.
Experimentally verified binding sites in their natural context and from SELEX experiments are listed in Additional file 1, Table S14 for the three SR proteins that we identified based on the expression data as possibly involved in general developmental roles (SRp55, SRp40 and ASF/SF2).
In general, developmental neurotoxicity appears to be an extremely sensitive end point, at least in mice.
