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These neomorphic mutations result in the gained function of converting α-KG to 2-hydroxyglutarate (2-HG), an oncometabolite.
However, up-regulation was observed for genes in the gained 11p12 region including ACP2, CUGBP1 and FNBP4 and in the gained 11q12.1-q14.3 interval for ATG2A, CABP3, NAALAD2, TncRNA, CTTN, RAB30 and EHBP1.
The resolution of array CGH technology combined with human genome database suggested the possible target genes present in the gained or lost clones.
In the gained weight group 6 patients had less than 24 months follow-up and 9 patients had 24 months or more follow-up.
PPM1D has been reported to be the most likely target of the 17q23 gain in NB tumors [ 46]; this gene was included in the gained region in all our tumors with 17q gain.
It has been proposed that when a mismatch is encountered, active misalignment of catalytic residues in the DNA polymerase results in reduced incorporation rate and therefore higher specificity of the enzyme.[ 27] Thus, discrimination could derive from differences in the gained substrate binding energy by misalignment of catalytic residues.
Similar(53)
You gain something; you sacrifice something else in the gaining of that thing.
The slowest growers in the index gained 8 percent.
Clemens began corralling his fastball in the third inning, gaining a comfortable consistency in his motion.
Shares of Anadarko Petroleum, a partner in the well, gained 1.8%.
Shares in the bank gained 8.6% to 327p.
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