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The maps produced as part of the project are based on context in the first instance, since register variation is precisely variation according to context of use.
Early preproliferative retinopathy is also generally not treated in the first instance, since such cases are monitored for progression to high risk features and sometimes these retinal signs can resolve with improvement of glycaemic control.
It would be valuable to repeat these models assuming that patients with abnormal but low-risk non-invasive tests are treated medically in the first instance, since the prognostic power of MPS is likely to lead to even greater cost-effectiveness.
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It was the first time a World Series game lost to an N.F.L. game in prime time and the first instance since 2002 that an N.F.L. game faced a World Series game on a Sunday night.
The cancellation of the high-profile publication, known as the A & F Quarterly, is thought to be the first instance since the attacks in which an advertiser has scrapped a big planned marketing effort poised to be printed.
But this was the first instance since the cleanup began in 1995, they said, that officials had been unable to gauge the magnitude of the problem.
This is the third instance since Church sustained his second concussion in less than three months, on May 20 in Atlanta, that he has told the Mets and reporters that he did not feel well.
But it is the second instance since of a state asserting its power to threaten an existing nuclear plant.
Since cytostasis is a reasonable outcome, in the first instance, and since we might reasonably expect to observe this during the development of other therapeutics, then perhaps this recommendation should be widened to include other therapeutic approaches.
What is striking about Mr. Davis's case is that in addition to the seven prosecution witnesses who recanted their trial testimony, three individuals have sworn that the person who pointed investigators toward Mr. Davis in the first instance has since confessed to the crime.
This is particularly so since in the first instance Government authorities may not be immediately convinced to commit budgetary allocations to this activity.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com