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In the first difficulty level, the number of correct responses (F = 0.747, p = 0.48), the number of errors (F = 0.539, p = 0.58), the number of omissions (F = 0.273, p = 0.76), and the reaction time (F = 1.355, p = 0.27) were similar among the three genotypes.
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In this paper, the first difficulty is alleviated by developing the hybrid boundary node method (HdBNM), which is a boundary-type meshless method.
Some students reluctantly initiate an activity, but lack persistence skills, stopping in their tracks at the first difficulty.
The first difficulty in such kind of work was to find closely similar work, since much of the available literature dealing with the choice of cutoff points do not focus on alternatives to estimate a fairly balanced cutoff point.
Rising behaviour was later also specifically assessed by animal husbandry staff when the first difficulty in getting up was noticed.
The first difficulty in assessing counterfactual causal effects is to choose the reference condition when comparing one treatment level t with another treatment level c, that is, the substantive meaning of "treatment c".
The first difficulty lies in choosing the physiological signals representation and in particular the electroencephalogram (EEG).
The first difficulty is in deciding the appropriate unit for measuring resources.
The first difficulty lies in the exact characterization of the breakpoints.
This shows that a significantly higher tendency of the inter-gene chain breaking is important for the spread of the chromosome, which supports our hypothesis that self-cleavage by the hammerhead ribozymes residing between genes may play an important role in overcoming the fourth difficulty, namely., the synthesis of distinct gene products from the chromosome.
One of the first difficulties in developing monoclonal antibody therapeutics was the recognition that human anti-mouse antibody (HAMA) response limited the administration of murine antibodies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com