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This makes it possible to exploit information about cross-section geometry limiting, at least partially, the uncertainty in the extrapolation of discharge at higher flow values.
The main reasons that so many methods have been proposed are as follows: The fact that many studies have a limited number of sampling data, different fitting curves have been used for various styles of eruptions, and there are inaccuracies involved in the extrapolation of fitted curves to the proximal and distal regions.
Additionally, it may be worth noting that in the extrapolation of their experimental data to infinite dilution by using the Pitzer equations, Altmaier et al. [79] employed 20 Pitzer parameters (12 binary interaction parameters and 8 ternary/mixing interaction parameters) to describe fully their experimental system when MgOH+ is ignored.
Note that the large error bars for ERB-041 at ERα (Figure 1A, open bars) reflects the variations in the extrapolation of the dose-response because maximal energy transfer was not achieved at 3 µM ERB-041 (the highest concentration used).
Therefore, we suggest caution in the extrapolation of our results.
Therefore, caution is needed in the extrapolation of our findings to other skin areas.
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Apart from the challenging molecular examination of cartilage characteristics in vivo, the extrapolation of data gained from animal models to the human situation in vivo is difficult, thus limiting direct conclusions.
For instance, evaluation of drug metabolism and drug drug interactions with intact human hepatocytes in 100% human serum may eliminate the need to determine in vivo intracellular concentrations for the extrapolation of in vitro data to in vivo.
Thirdly, because DIF by age has repeatedly been found for many items in measures of PF, the extrapolation of our results beyond samples of older people is questionable.
Another relevant aspect that could harm the extrapolation of in vitro results to the in vivo scenario was the lack of consideration of interspecies differences.
The extrapolation of in vitro retrieval study results to in vivo conclusions may therefore not always be appropriate.
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