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These projected studies will provide insight into the pharmacokinetics and pharmacodynamics of MDR1 inhibitors in vivo and allow for optimization of combination therapies (strategy for dual administration of MDR1i with primary chemotherapeutic).
However, a dual administration of blocking antibodies to PD-1 and Tim-3 failed to reduce HCV loads in C/OTg mice (Fig. 1i).
In August 1858 Dorion formed a dual administration with George Brown, the attorney general of Canada West, but they resigned after three days.
The puzzle consists in the dual possibilities of the atom that serves as the trigger.
Braugher is very good in the dual roles of the Dukes.
Both dancers were visibly feeling their way in the dual ballerina roles of Odette and Odile.
In the same line of evidence it was demonstrated that the chronic administration of the dual reuptake inhibitor venlafaxine induces the nuclear translocation of beta-catenin most likely by an inhibition of GSK3β through AKT/PKB signalling [ 74].
An example of a dual therapy that is used in the United States is the administration of a cephalosporin, such as cefixime or ceftriaxone, in combination with azithromycin (a macrolide antibiotic) or doxycycline (a tetracycline antibiotic).
Holbrooke served in the administration of Pres.
In March the administration of Pres.
Flavocoxid administration succeeded in reducing these steps of the inflammatory cascade, thus suggesting that the dual inhibitor of COX-2 and 5-LOX may work as an NF-κB inhibitor.
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