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The presence of the COO− groups would result in the disassembling of the hydrogen-bonding network because of Coulomb repulsion [29].
The phosphorylated tau protein results in the disassembling of microtubules and aggregates to form neurofibrillary tangles, a hallmark of AD pathology.
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The expression profile of these two cytoskeletal proteins in the holothurian suggests two hypotheses: First, that down-regulation of this actin isoform may be indicative of changes in cytoskeleton dynamics, probably the disassembling of the actin network; and second, down-regulation of alpha-actinin may be related to changes in cell adhesion and motility.
The disassembling of RR structures in the presence of an anti-IMPDH2 antibody strongly indicates that IMPDH2 enzyme is an important element in RR, analogous to the demonstration of dynein as the motor in Golgi organization.
At the adhesion, large complexes containing several paxillin molecules associate with other molecules in the assembling or disassembling of the adhesions.
This inactivation is in agreement with the unfolding and disassembling of the particle described for this protein at pH<4.0 [28].
In addition, copolymers contain biodegradable linkages between hydrophilic polymer chains and hydrophobic molecules in order to allow disassembling of the supramolecular structure after completing their drug carrier function and renal removal of copolymers from the body.
The beams were left in the mold for 48 h before disassembling of the mold and were then covered with wet burlap for 28 days before testing.
A subset of the cardiomyocytes showed completely diffuse staining for alpha-actinin (asterisk in Fig. 5); however, DAPI revealed that these were dividing cardiomyocytes in the process of disassembling their myofibrils (Ahuja et al., 2004).
Another advantage of the lack of hydrolysis is that no destabilization occurs allowing observation of the initial interaction steps in the complete absence of disassembling structures and under conditions satisfying the law of mass action.
This latter observation leads to a model for the movement (sliding) of adhesions in which the leading and trailing ends of the adhesions are assembling and disassembling in concert with the addition of single paxillin molecules or small complexes to the assembling border and large aggregates leaving the disassembling end.
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