However, differences in dose, time, and tissue, as well as coexposures, can result in differing mechanisms and complicate the interpretation of disease risk under varying exposure conditions.
Trials are currently ongoing attempting to prospectively validate PET results as a predictor of outcome (criterion 3), but the fourth point, determination of the utility of PET in the setting of treatments with differing mechanisms of action, will be an ongoing challenge.
Interestingly these genes participate in the oxidative stress response through differing mechanisms.
The two models for the clavata1-1 mutant differ in the direct mechanism of the mutant, but they also predict other differences in the dynamics of the stem cell regulating network.
We investigated plumage patches which differed in the main mechanism of colour production, distinguishing structural, carotenoid- and melanin-based colours.
Two classes of TEs exist that differ in the molecular mechanism by which they transpose from one genomic location to another: Class I TEs (retrotransposons) transpose via a "copy and paste" mechanism, utilizing an RNA intermediate, and generating a new TE copy that inserts into a novel genomic location.
Two classes of TEs exist that differ in the molecular mechanism by which they transpose from one genomic location to another – Class I TEs (retrotransposons) transpose via an RNA intermediate, whereas Class II TEs (DNA transposons) transpose via a DNA intermediate [ 1, 2].
They differ in the mechanism they use for radical generation, structural differences and oxygen dependence.
A remarkable observation was that PKCs were hyperphosphorylated in PC3 than in 293T (Figure 3D) suggesting that the two cell lines could significantly differ in the PA-mediated mechanism of mTOR activation.
Like MEX-3C, Roquin localizes to cytosolic RNA granules implicated in mRNA stability, though they differ in the mechanism for mRNA decay.
