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Clinical differences between the patients with RA included in the different reports are possible and difficult to exclude.
It is also interesting to note that the aspects analysed are different in the different reports.
In the different reports vasoconstriction was diagnosed by arteriography between two days and three weeks after the onset of headache in 18 of the reported cases.
It has previously been shown that COX-2 is upregulated in subsets of pancreatic, ampullary and distal bile duct adenocarcinomas although the proportion of upregulated tumours varies in the different reports.
Furthermore, throughout their paper Trock et al stressed the difficulties imposed on their study by, for example, the various methodologies employed in the different reports that they considered, the heterogeneity of the patient populations studied, and the different reactivity patterns of the monoclonal antibodies used when performing immunohis-tochemistry.
As a control group, we used a group of female donors over the age of 50 years, to reduce the possibility that control donors will develop the disease in the future, as the reported mean age of onset ranges from 58 to 75 years in the different reports.
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The amount of senescent cells was evaluated in the different reported conditions by using the Senescence β-Galactosidase Staining Kit (Abcam, Cambridge, UK) in accordance to the manufacturer's instructions, as previously described [ 15].
The distribution of the three genotypes is not significantly different in this study compared to the different reports in Caucasian populations.
First, it might be due to genetic heterogeneity (both allelic and locus heterogeneity) in different ethnic populations or the different reporting criteria for a P value.
The different reporting systems consulted in this study each rely on particular reporters to obtain the information and the scope of drugs presented in the reporting system differs between different reporting systems.
Vitamin D levels in the different study groups are reported in Table 2 and illustrated in Figure 1.
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