The correlation coefficients (r2) were found to be consistently ≥0.996 during the course of validation.
The determination coefficients (r2) were consistently greater than 0.995 during the course of validation.
Since the proteins in the MD subnetwork are quite diverse, we examined the protein pairs in the network and found that of the 83 interacting pairs 17 had been validated by GST-APs in the course of our validation of this Y2H screen and the previously published data in Lim et al. (15).
In the course of the validation studies, it was obvious that there were no items from the adapted test version which matched to these characteristics.
In the course of this validation we discovered an extreme sensitivity to the pre-processing methodology.
In the course of investigating the validation of the technology for quality assurance applications, intra- and inter-instrument variability studies have been performed for optimized instruments using a model aggregate population and model measurement protocol.
In the following, the method for this survey and its results are presented.b Owing to the low response rate and the inherent methodological challenges we found in the course of this first validation study of reason-codings, our discussion focuses on these issues – not only in regard to our study, but also with a view to future validation studies of SRRs.
Subsequently, we predicted causal genes for each of the disorders at a P-value threshold of 0.01 and an overlap threshold of 2. The bar plots in Fig. 5 list all genes that were predicted in the course of 20 cross-validation rounds and show the fraction of samples in which the genes were encountered.
Further progress, in the course of this project, will move the technique from the pilot phase to a clinical validation phase.
