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The function of methylation in mammals depends on the context of the modification within the genome.
However, the significance of these modifications in the context of the pathology of BKV and BKVAN remains to be determined.
However, in the context of the de-localized Pc2 2-531) construct, modification by SUMO1 of both Pc2 and CtBP was reduced by these point mutations (Figure 5C).
Since the alanine mutations surrounding SIM1 appeared to affect modification by both SUMO1 and SUMO2, in the context of the amino-terminal Pc2 fusions, we next compared modification of CtBP and full length Pc2 by SUMO1 and SUMO2 in parallel.
The use of HSA as a biomarker has primarily been described in the context of electrophilic modifications at Cys34.
Mr. Stevens said the modification program should be considered in the context of the administration's broader efforts to shore up the housing market.
These previously published reports have not, however, addressed the physiological role of this modification in vivo in the context of the immune system.
These modifications could have significance in the context of the nuclear milieu.
Most DNA modification in mammals is the methylation of cytosine (5mC) in the context of the CG dinucleotide [ 1– 3].
Indeed, chromatin modifications are tightly associated with the vernalization pathway in the context of the epigenetic repression of floral inhibitors.
This phenomenon has largely been studied in the context of chromatin modification.
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