Understanding the effect of individual mutations in the context of the remaining genomic variation represents a major challenge to our interpretation of disease.
This principle, although (much) weaker than AC, cannot be proved without it in the context of the remaining axioms of set theory.
In the context of the remaining proteins, the similarity of human and avian H5N1 entropy patterns is consistent with the observations that, to date, all human H5N1 isolates represent avian to human transmission from isolated clusters of avian infection.
Parameter optimization is done on the hybrid models, optimizing the parameters for that single set of MRL reactions alone in the context of the remaining ARL network.
This discussion will therefore focus on the representation and decomposition of sequence conservation, which can be detected by unlikely repetition of the conserved segment of because the conserved segment has an unlikely composition in the context of the remaining sequence.
To evaluate the performance of the MRL model for the coupled-enzyme system, we simultaneously replaced ARL pathways corresponding to glycolysis (9 separate ARL reactions) with their MRL versions in the context of the remaining ARL model.
However, the amplification status and function of GAB2 in the context of amplification remain undefined.
The targets that SIRT1 deacetylates in the context of mitosis remain undefined.
While the exact implications for the function of Atx1 in the context of splicing remain to be investigated in detail, it is worth noting that only non-expanded Atx1 seems to have a significant effect on U2AF65-mediated splicing suggesting that polyQ expansion could interfere with molecular recognition.
The clinical implications of such effects in the context of CPB remain unknown.
The genomic positions and temporal programs of metazoan replication origins have been determined within various cell types by genome-wide sequencing analysis (Gilbert 2010), but the mechanisms that regulate recruitment of replication initiation factors to origins of replication and how origins of replication are activated, especially in the context of development, remain poorly understood.
