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Such a model could serve as an important adjunct to clinical judgment in order to identify patients with cirrhosis who are highly unlikely to benefit from initiating aggressive treatment or continuing treatment in an ICU, especially in the context of prioritization for ICU bed allocation and the high cost of current treatment.
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Our metric provides a measure of the functional similarity between two genes and its reliability is tested in this paper in the context of gene prioritization for NSHL.
Recently, EFSA delivered a scientific report recommending for future work and research the use of omics technologies and AOPs in the context of the prioritization of chemicals for risk assessment [ 44].
Policy space contracted during the mid-1990s in the context of weakening prioritization of reproductive health in national and international policy agendas, undermining access to contraceptive services and contributing to the stalling of the country's fertility rates.
In the context of gene prioritization problems, we can assess the likelihood that a given gene belongs to a given MeSH category M on the basis of the M-labeled genes directly connected to the gene under study.
In the context of disease gene prioritization, random walk with restarts is applied as follows.
The conclusions outline the main findings of this work and suggest novel research lines in the context of the gene prioritization and network integration problems.
However, we did not find a simple framework or checklist that could have been deployed in the context of the assigned prioritization task.
HSAs performed a variety of tasks in addition to those outlined in the job description resulting in issues of overloading, specialization and competing demands existing in the context of task-shifting and prioritization.
In the context of "network medicine", gene prioritization methods represent one of the main tools to discover candidate disease genes by exploiting the large amount of data covering different types of functional relationships between genes.
Even if any valid kernel K can be applied to compute the above proposed scores, in the context of network-based gene prioritization, we used random walk kernels [53], since they can capture the similarity between genes, taking into account the topology of the overall functional interaction network.
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